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Background and Objectives: Nystagmus has a negative effect on the patient's quality of life (QoL), leading to an increase in their dependence on others and a decrease in self-confidence and social relationships. Therefore, effective treatment and management are crucial in restoring those affected's visual function and social life. To determine whether contact lens (CL) use impairs the vision of infantile nystagmus (IN) patients, this study conducts a systematic review of the relevant literature.
Methods: This systematic review adhered to the guidelines of the preferred reporting items for systematic reviews and meta-analyses (PRISMA). We searched databases including PubMed, Scopus, Google Scholar, and the Cochrane Central Register of Controlled Trials for relevant studies published up to May 9, 2022. The search was not limited by study type (except for review articles), publication time, or language. We used medical subject headings (MeSH) and keywords such as “nystagmus,” “CL,” “congenital nystagmus,” “IN,” “rigid gas permeable lenses,” and “soft CLs”.
Results: Initially, 102 articles were identified. After removing duplicates, 76 articles remained. Of these, 39 were excluded during screening for irrelevance, and 8 were excluded due to inaccessible abstracts or full texts. Ultimately, 29 articles were included in this review.
Conclusion: The majority of studies reviewed reported no significant side effects from using CLs, and most patients achieved similar or improved visual function compared to using glasses. As a result, even if CLs are not superior to glasses, they perform comparably and can be considered a primary treatment option when there are indications for prescribing CLs.

Keywords: Vision rehabilitation, Contact lenses (CLs), Infantile nystagmus (IN), Systematic review, Congenital nystagmus, Rigid gas permeable lenses, Quality of life (QoL)

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