fa آموزش و تمرین حرفه ای Professional education and practice پژوهشي Research <strong>Background and Objectives: </strong>The present study was conducted with the aim of investigating and estimating the relationship between anxiety and occupational stress with the self-efficacy of therapists in rehabilitation centers in Tehran in 2022.<br> <strong>Methods:</strong> This research was applied in terms of purpose and descriptive-survey in terms of execution. The statistical population including 122 therapists of rehabilitation centers was done by multi-stage classification method. The research tools included standard questionnaires: Beck&rsquo;s anxiety questionnaire (1991), Osipow&rsquo;s job stress questionnaire (1987) and Riggs and Knight&rsquo;s job self-efficacy questionnaire (1994).Their analysis was done by SPSS software, version 26 at two descriptive and analytical levels.<br> <strong>Results: </strong>The results showed that there is a significant inverse effect between anxiety and self-efficacy, as well as occupational stress and self-efficacy of therapists (P<0.001). There is also a significant relationship between job stress, anxiety, self-efficacy and demographic characteristics.<br> <strong>Conclusion:</strong> The results of this study showed that anxiety increases the level of occupational stress and has a negative effect on therapists&rsquo; self-efficacy. Anxiety, Occupational stress, Self-efficacy, Therapists of rehabilitation centers 0 0 http://fdj.iums.ac.ir/browse.php?a_code=A-10-312-1&slc_lang=fa&sid=1 Eisa Sheikhi eesa.sheikhy@yahoo.com 10031947532846003428 0009-0008-6631-0147 No Department of Rehabilitation Management, Rehabilitation Research Center, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran. Mohammad Kamali Kamali.Mo@Iums.ac.ir 10031947532846003429 10031947532846003429 No Department of Rehabilitation Management, Rehabilitation Research Center, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran. Seyed Hassan Saneii Saneii.h@iums.ac.ir 10031947532846003430 10031947532846003430 No Department of Rehabilitation Basic Sciences, Rehabilitation Research Center, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran. Mahtab Roohi-Azizi Roohiazizi14@yahoo.com 10031947532846003431 10031947532846003431 Yes Department of Rehabilitation Basic Sciences, Rehabilitation Research Center, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran.