en کاردرمانی Occupational Therapy پژوهشي Research <span style="font-size:14px;"><span style="font-family:Tahoma;"><strong>Background and Objectives:</strong> The prevalence of autism has increased worldwide in recent decades. The diagnosis of autism requires deficits in communication and social interaction skills, such as holding a back-to-back conversation and using non-verbal communication behaviors. It seems that the social skills of students with autism may significantly affect their self-determination state because the problem of social interaction causes limitations in autonomous functioning. Therefore, this study aims to examine the effect of occupation-based self-determination intervention on the communication and interaction skills of adolescents with autism spectrum disorder (ASD).<br> <strong>Methods</strong>: This randomized clinical trial was conducted on 40 adolescents with ASD. A total of 21 adolescents (intervention group) were randomly selected to participate in the occupation-based self-determination intervention, while the other 19 adolescents (control group) had only routine occupational therapy sessions. All these adolescents were assessed before, after, and 45 days after the 16-session intervention program using an assessment of communication and interaction skills. Data were analyzed using non-parametric chi-square test and parametric tests (repeated measures analysis of variance (ANOVA) and student&rsquo;s t-test).<br> <strong>Results</strong>: A significant change was observed in the assessment results of the communication and interaction skills between pre and post-test of the intervention group. After analyzing the results with multivariate test, repeated measures, and student&rsquo;s t-test, it was revealed that while the mean scores for communication and interaction skills in the control group did not show significant changes during assessment times (P>0.05), the comparison between groups over time for communication and interaction skills indicated a statistically significant increase in the intervention group (P<0.001).<br> <strong>Conclusion</strong>: Using occupations to instruct self-determination skills to adolescents with ASD is an effective method to enhance their performance skills, including communication and interaction skills.</span></span><br> &nbsp; Autism spectrum disorder, Personal autonomy, Social participation, Adolescent, Occupational therapy, Communication, Social skill 0 0 http://fdj.iums.ac.ir/browse.php?a_code=A-10-266-1&slc_lang=en&sid=1 Mohammad Naghavi Kheslat mohamad.naghavi97@gmail.com 10031947532846003182 0009-0007-3082-865X No Department of Occupational Therapy, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran. گروه آموزشی کاردرمانی، دانشکده علوم توانبخشی، دانشگاه علوم‌پزشکی ایران، تهران، ایران. Mahdi Alizadeh Zarei alizadeh.m@iums.ac.ir 10031947532846003183 10031947532846003183 Yes Department of Occupational Therapy, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran. Elahe Hojati Abed hojatiabed.e@iums.ac.ir 10031947532846003184 10031947532846003184 No Department of Occupational Therapy, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran.